Supports intestinal health in adults and children
•    Provides live microorganisms that temporarily modify gut flora
•    Provides 20 billion CFU per daily dose from: Lactobacillus acidophilus (CUL-60), Lactobacillus acidophilus (CUL-21), Bifidobacterium bifidum (CUL-20), Bifidobacterium animalis subsp. lactis (CUL-34)

HMF Forte is a combination of four strains of proprietary probiotics that help promote gastrointestinal health in adults and children. Supplementation with large numbers of a combination of microorganisms will help maximize intestinal colonization, promoting the growth of beneficial bacteria.¹ In a randomized, placebo-controlled trial involving 22 adults, daily supplementation with a probiotic containing Lactobacillus acidophilus (CUL-60 and CUL-21) stimulated the restoration of microflora after it was altered by antibiotics.² Likewise, research also demonstrates that a probiotic supplement containing CUL-21 can significantly colonize the gut of healthy adults.³ Lactobacilli and Bifidobacteria are the most commonly used probiotics, and are safe for both adults and children.⁴ They successfully colonize the intestines, increase the release of antimicrobial peptides from host cells, and decrease the proliferation of pathogens.⁴ Probiotics also control the permeability of epithelial cells by mediating tight junction formation, and prevent pathogenic adherence to cells by increasing mucin release on the intestinal surface.⁴

REFERENCES
1. Allen, SJ, Wareham, K, Bradley, C, Harris, W, Dhar, A, Brown, H, Foden, A, Cheung, WY, Gravenor, MB, Plummer, S, Phillips, CJ, Mack, D. BMC Infectious Diseases. 2012; 12: 108.
2. Madden, JAJ, Plummer, SF, Tang, J, Garaiova, I, Plummer, NT, Herbison, M, Hunter, JO, Shimada, T, Cheng, L, Shirakawa, T. International Immunopharmacology. 2005; 5: 1091-1097.
3. Mahenthiralingam, E, Marchbank, A, Drevinek, P, Garaiova, I, Plummer, S. BMC Microbiology. 2009; 9: 251.
4. Saulnier, N, Zocco, MA, Di Caro, S, Gasbarrini, G, Gasbarrini, A. Genes & Nutrition. 2006; 1(2): 107-116.